SMAD1

Across TCGA cell cohorts, SMAD1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMAD1-associated genes across cancer lineages are ITGAD, NPY2R, and BPIFA1. Each is linked with SMAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMAD1-to-partner and partner-to-SMAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by SMAD1-low versus SMAD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMAD1→partner) and Y-score (partner→SMAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	BPIFA1 →	+0.166	+3.103	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PTX4 →	+0.128	+3.520	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ITGAD by SMAD1 expression — LARGE_INTESTINE

Explore this box plot interactively →