SMAD1-AS2

Across TCGA pan-cancer cohorts, SMAD1-AS2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SMAD1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SMAD1-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMAD1-AS2 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

STAD and BRCA are the cancer types where SMAD1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMAD1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	All	+0.077	.026	2	view →
BRCA	All	III,IV	−0.053	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SMAD1-AS2–STAD

Open the STAD breakdown →