SLTM

Across TCGA patient cohorts, SLTM mutation is significantly associated with the RNA expression of many other genes, with 5,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLTM-associated genes across cancer lineages are CXXC4, CENPM, and GOT1. Each is linked with SLTM in more than 3 cancer types. Because this analysis shows association rather than direction, both SLTM-to-partner and partner-to-SLTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXXC4 grouped by SLTM-low versus SLTM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLTM→partner) and Y-score (partner→SLTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXXC4 →	-0.474	-1.904	.005	.004	3	4
UCEC	CENPM →	+0.658	+2.039	<.001	<.001	3	4
UCEC	GOT1 →	+0.373	+1.912	<.001	<.001	3	4
UCEC	SKA1 →	+0.800	+1.858	<.001	<.001	3	3
UCEC	CCNB2 →	+0.751	+1.847	<.001	<.001	3	3
UCEC	AZGP1 →	-0.733	-1.896	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,323 associations by consensus.

CXXC4 by SLTM expression — UCEC

Explore this box plot interactively →