SLTM

Across TCGA patient cohorts, SLTM mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLTM-associated genes across cancer lineages are PCNA, mTOR_pS2448, and ATM. Each is linked with SLTM in more than 3 cancer types. Because this analysis shows association rather than direction, both SLTM-to-partner and partner-to-SLTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SLTM-low versus SLTM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLTM→partner) and Y-score (partner→SLTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.242	+3.169	<.001	<.001	3	4
UCEC	mTOR_pS2448 →	-0.143	-2.649	.001	<.001	3	3
UCEC	ATM →	-0.632	-1.857	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.787	+3.392	<.001	<.001	3	3
UCEC	eIF4E →	+0.186	+3.820	.002	<.001	3	2
UCEC	GAPDH →	+0.387	+1.999	.014	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PCNA by SLTM expression — UCEC

Explore this box plot interactively →