SLTM

Across TCGA cell cohorts, SLTM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,221 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLTM-associated GO terms across cancer lineages are Positive regulation of nuclear cell cycle DNA replication, DNA replication, and RNA catabolic process. Each is linked with SLTM in more than 16 cancer types. Because this analysis shows association rather than direction, both SLTM-to-partner and partner-to-SLTM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear cell cycle DNA replication grouped by SLTM-low versus SLTM-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLTM→partner) and Y-score (partner→SLTM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of nuclear cell cycle DNA replication →	+0.204	+0.824	<.001	<.001	3	17
BONE	DNA replication →	+0.110	+0.672	.003	.004	3	16
UPPER_AERODIGESTIVE_TRACT	RNA catabolic process →	+0.065	+0.887	.001	<.001	3	16
URINARY_TRACT	Promoter clearance during DNA-templated transcription →	+0.116	+0.851	<.001	<.001	3	16
URINARY_TRACT	RNA polymerase II promoter clearance →	+0.116	+0.851	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.117	+0.893	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,221 associations by consensus.

Positive regulation of nuclear cell cycle DNA replication by SLTM expression — LIVER

Explore this box plot interactively →