SLITRK5

Across TCGA cell cohorts, SLITRK5 mutation is significantly associated with the RNA expression of many other genes, with 1,338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLITRK5-associated genes across cancer lineages are GMCL1, PXMP2, and GDPGP1. Each is linked with SLITRK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLITRK5-to-partner and partner-to-SLITRK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMCL1 grouped by SLITRK5-low versus SLITRK5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLITRK5→partner) and Y-score (partner→SLITRK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GMCL1 →	+0.628	+3.380	.004	.001	3	3
LARGE_INTESTINE	PXMP2 →	+0.563	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	GDPGP1 →	+0.531	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	ANAPC5 →	+0.285	+2.569	.004	.003	3	3
URINARY_TRACT	SEBOX →	+0.056	+4.584	<.001	.002	3	2
CNS	INSL4 →	+0.033	+3.479	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,338 associations by consensus.

GMCL1 by SLITRK5 expression — BLOOD_Leukemia

Explore this box plot interactively →