SLITRK4

Across TCGA pan-cancer cohorts, SLITRK4 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SLITRK4 data layer compared with 29 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLITRK4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SLITRK4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, OV, and LUSC are the cancer types where SLITRK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.953	0.463	.002	36	view →
OV	DFS	Median	All	0.248	0.543	.006	18	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
READ	DFS	Median	II,III,IV	0.388	0.824	.019	9	view →
HNSC	OS	Median	III,IV	1.000	0.363	.013	9	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
ESCA	OS	Median	II,III,IV	0.298	0.555	.031	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
BRCA	OS	Median	All	0.190	0.579	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SLITRK4–UCEC (DFS)

Open the UCEC breakdown →