SLITRK4

Across TCGA patient cohorts, SLITRK4 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLITRK4-associated genes across cancer lineages are PCNA, Src_pY527, and STAT3_pY705. Each is linked with SLITRK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLITRK4-to-partner and partner-to-SLITRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SLITRK4-low versus SLITRK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLITRK4→partner) and Y-score (partner→SLITRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.197	+1.722	<.001	<.001	3	3
COAD	Src_pY527 →	-0.394	-2.982	.008	.034	3	3
UCEC	STAT3_pY705 →	-0.362	-2.115	<.001	<.001	3	3
COAD	ASNS →	+0.418	+2.230	.005	.006	3	3
COAD	Caspase-7-cleavedD198 →	+0.959	+1.708	.001	.026	3	3
UCEC	4E-BP1 →	+0.310	+2.247	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

PCNA by SLITRK4 expression — UCEC

Explore this box plot interactively →