Across TCGA patient cohorts, SLITRK2 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLITRK2-associated genes across cancer lineages are eEF2, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with SLITRK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLITRK2-to-partner and partner-to-SLITRK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLITRK2→partner) and Y-score (partner→SLITRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.284	+1.593	.014	.043	3	4
UCEC	Cyclin-B1 →	+0.566	+2.201	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.139	+3.186	<.001	.009	3	3
COAD	PCNA →	+0.278	+3.182	.004	.009	2	4
COAD	Smad4 →	+0.107	+3.169	.040	.017	3	3
COAD	TFRC →	+0.576	+2.832	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

SLITRK2 survival (RNA) · tumor vs normal (RNA) · all SLITRK2 data types