SLITRK1

Across TCGA patient cohorts, SLITRK1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLITRK1-associated genes across cancer lineages are Cyclin-B1, FASN, and Rb_pS807_S811. Each is linked with SLITRK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLITRK1-to-partner and partner-to-SLITRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SLITRK1-low versus SLITRK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLITRK1→partner) and Y-score (partner→SLITRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.491	+1.777	<.001	.001	3	4
LUSC	FASN →	+0.401	+2.009	.024	.018	3	4
SKCM	Rb_pS807_S811 →	+0.277	+1.157	.022	.012	3	4
UCEC	eEF2 →	+0.322	+1.736	<.001	.005	3	3
SKCM	GAPDH →	+0.390	+1.765	.017	.010	3	3
UCEC	ATM →	-0.524	-1.898	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Cyclin-B1 by SLITRK1 expression — UCEC

Explore this box plot interactively →