Across TCGA patient cohorts, SLIT3 mutation is significantly associated with the RNA expression of many other genes, with 7,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLIT3-associated genes across cancer lineages are CCNF, STOML2, and STIP1. Each is linked with SLIT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLIT3-to-partner and partner-to-SLIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT3→partner) and Y-score (partner→SLIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNF →	+0.534	+1.702	<.001	<.001	3	5
UCEC	STOML2 →	+0.345	+2.000	<.001	<.001	3	5
UCEC	STIP1 →	+0.384	+1.691	<.001	<.001	3	5
UCEC	ERP27 →	-0.950	-2.104	<.001	<.001	3	5
CESC	SET →	+0.440	+3.189	.005	.008	3	5
CESC	ACKR1 →	-1.506	-3.575	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,248 associations by consensus.

Exploration

SLIT3 survival (RNA) · tumor vs normal (RNA) · all SLIT3 data types