Across TCGA patient cohorts, SLIT3 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLIT3-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and Cyclin-B1. Each is linked with SLIT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLIT3-to-partner and partner-to-SLIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT3→partner) and Y-score (partner→SLIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.718	+3.169	.020	.018	2	5
UCEC	FASN →	+0.225	+1.523	.029	.006	3	4
UCEC	Cyclin-B1 →	+0.673	+4.459	<.001	<.001	3	4
LUAD	Caveolin-1 →	-0.642	-1.807	.008	.022	3	3
STAD	C-Raf →	+0.169	+3.169	.011	.018	3	3
UCEC	PARP_cleaved →	-0.167	-1.263	.038	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

SLIT3 survival (RNA) · tumor vs normal (RNA) · all SLIT3 data types