Across TCGA cell cohorts, SLIT3 mutation is significantly associated with the RNA expression of many other genes, with 517 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLIT3-associated genes across cancer lineages are KCTD9, USP46, and TSPAN2. Each is linked with SLIT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLIT3-to-partner and partner-to-SLIT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT3→partner) and Y-score (partner→SLIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCTD9 →	+0.676	+2.949	.004	<.001	3	2
LARGE_INTESTINE	USP46 →	+0.572	+2.351	.003	.001	3	2
LARGE_INTESTINE	TSPAN2 →	-0.912	-3.459	.005	.001	3	2
LARGE_INTESTINE	BTF3L4 →	+0.680	+3.321	<.001	.002	3	2
LARGE_INTESTINE	PPA2 →	+0.629	+2.649	<.001	.001	3	2
LARGE_INTESTINE	NUF2 →	+0.451	+3.257	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

Exploration

SLIT3 survival (RNA) · tumor vs normal (RNA) · all SLIT3 data types