SLIT2

Across TCGA patient cohorts, SLIT2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,032 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SLIT2-associated genes across cancer lineages are PTGIS, JAM3, and CNRIP1. Each is linked with SLIT2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SLIT2-to-partner and partner-to-SLIT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLIT2 versus PTGIS in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT2→partner) and Y-score (partner→SLIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTGIS →	+1.397	+0.668	<.001	<.001	3	8
BRCA	JAM3 →	+0.800	+0.517	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.801	+0.516	<.001	<.001	3	7
OV	CD93 →	+0.906	+0.369	<.001	<.001	3	7
UCEC	CNN1 →	+1.949	+0.496	<.001	.003	3	7
CCRCC	PDGFRA →	+1.261	+0.415	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,032 associations by consensus.

SLIT2 vs PTGIS — UCEC

Explore this scatter interactively →