SLIT2

Across TCGA patient cohorts, SLIT2 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLIT2-associated genes across cancer lineages are PDCD4, Cyclin-B1, and Ku80. Each is linked with SLIT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLIT2-to-partner and partner-to-SLIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLIT2-low versus SLIT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT2→partner) and Y-score (partner→SLIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.431	-1.575	<.001	.004	3	4
UCEC	Cyclin-B1 →	+0.741	+2.584	<.001	<.001	3	4
UCEC	Ku80 →	+0.224	+1.363	<.001	.008	3	4
UCEC	PCNA →	+0.230	+2.087	<.001	<.001	3	4
STAD	FoxM1 →	+0.327	+3.169	.001	.017	3	3
STAD	FOXO3a_pS318_S321 →	-0.180	-1.679	.010	.042	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

PDCD4 by SLIT2 expression — UCEC

Explore this box plot interactively →