SLIT2

Across TCGA cell cohorts, SLIT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,024 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLIT2-associated GO terms across cancer lineages are Negative regulation of lamellipodium assembly, Regulation of retinal ganglion cell axon guidance, and Apoptotic process involved in luteolysis. Each is linked with SLIT2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SLIT2-to-partner and partner-to-SLIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lamellipodium assembly grouped by SLIT2-low versus SLIT2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT2→partner) and Y-score (partner→SLIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of lamellipodium assembly →	-0.225	-1.488	.008	<.001	3	15
SOFT_TISSUE	Regulation of retinal ganglion cell axon guidance →	+1.753	+3.480	<.001	<.001	3	14
OESOPHAGUS	Apoptotic process involved in luteolysis →	+1.445	+1.818	<.001	.002	2	13
OESOPHAGUS	Negative regulation of smooth muscle cell chemotaxis →	-0.211	-2.042	.001	.001	3	12
URINARY_TRACT	Negative regulation of lamellipodium organization →	-0.153	-2.164	<.001	.002	3	9
BREAST	Lactate metabolic process →	+0.190	+1.612	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,024 associations by consensus.

Negative regulation of lamellipodium assembly by SLIT2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →