SLIT2

Across TCGA cell cohorts, SLIT2 mutation is significantly associated with the RNA expression of many other genes, with 503 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLIT2-associated genes across cancer lineages are DTWD1, LRFN2, and KLHL40. Each is linked with SLIT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLIT2-to-partner and partner-to-SLIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTWD1 grouped by SLIT2-low versus SLIT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT2→partner) and Y-score (partner→SLIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DTWD1 →	+0.493	+3.169	.009	.006	3	3
BLOOD_Myeloma	LRFN2 →	+0.067	+4.285	.004	.003	3	2
BLOOD_Myeloma	KLHL40 →	+0.019	+3.906	<.001	.009	3	2
BLOOD_Myeloma	OR10AC1 →	+0.034	+4.285	.001	.003	3	2
OESOPHAGUS	IFNA2 →	+0.022	+2.857	<.001	.007	3	2
BLOOD_Leukemia	CFAP97D2 →	+0.255	+2.247	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 503 associations by consensus.

DTWD1 by SLIT2 expression — LARGE_INTESTINE

Explore this box plot interactively →