SLIT2-IT1

Across TCGA pan-cancer cohorts, SLIT2-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SLIT2-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLIT2-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLIT2-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and THCA show a favorable association.

ACC, UCS, and UCEC are the cancer types where SLIT2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.149	0.777	<.001	118	view →
UCS	OS	Median	II,III,IV	0.598	0.208	.002	98	view →
UCEC	DFS	Tertile	II,III,IV	0.713	0.860	<.001	90	view →
CHOL	DFS	Tertile	All	0.090	0.581	.003	45	view →
THCA	DFS	Quartile	All	0.958	0.872	.002	39	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	36	view →
KIRC	DFS	Tertile	IV	0.314	0.627	.015	30	view →
CESC	OS	Tertile	All	0.923	0.775	.022	30	view →
SARC	DFS	Quartile	All	0.137	0.462	<.001	26	view →
LUSC	DFS	Median	II,III,IV	0.838	0.517	.004	21	view →
UVM	DFS	Tertile	III,IV	0.129	0.688	.007	18	view →
THYM	DFS	Tertile	II,III,IV	0.719	0.965	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SLIT2-IT1–ACC (OS)

Open the ACC breakdown →