Across TCGA patient cohorts, SLIT1 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLIT1-associated genes across cancer lineages are Notch1, Cyclin-B1, and 14-3-3_beta. Each is linked with SLIT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLIT1-to-partner and partner-to-SLIT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT1→partner) and Y-score (partner→SLIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Notch1 →	+0.114	+2.819	.046	.035	3	5
UCEC	Cyclin-B1 →	+0.679	+2.321	<.001	<.001	3	4
SKCM	14-3-3_beta →	-0.112	-2.321	.015	.001	3	3
UCEC	4E-BP1 →	+0.334	+1.874	<.001	<.001	3	3
UCEC	PCNA →	+0.259	+2.087	<.001	<.001	3	3
UCEC	RAD51 →	+0.079	+1.321	.043	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

SLIT1 survival (RNA) · tumor vs normal (RNA) · all SLIT1 data types