Across TCGA cell cohorts, SLIT1 mutation is significantly associated with the RNA expression of many other genes, with 971 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLIT1-associated genes across cancer lineages are OR8B2, TAS2R9, and PRKACG. Each is linked with SLIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLIT1-to-partner and partner-to-SLIT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLIT1→partner) and Y-score (partner→SLIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B2 →	+0.071	+3.604	<.001	.004	3	2
LUNG_NSCLC_LUAD	TAS2R9 →	+0.039	+3.695	.003	.005	3	2
CNS	PRKACG →	+0.027	+4.169	<.001	.008	3	2
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	BOD1L2 →	+0.006	+4.906	<.001	.006	3	1
LIVER	OCM →	+0.075	+3.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 971 associations by consensus.

Exploration

SLIT1 survival (RNA) · tumor vs normal (RNA) · all SLIT1 data types