SLFNL1

Across TCGA pan-cancer cohorts, SLFNL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLFNL1 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLFNL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLFNL1 expression acts as an unfavorable survival marker.

LIHC, LAML, and UCEC are the cancer types where SLFNL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.028	0.777	<.001	24	view →
LAML	DFS	Median	All	0.082	0.582	.004	12	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLFNL1–LIHC (OS)

Open the LIHC breakdown →