SLFNL1

Across TCGA patient cohorts, SLFNL1 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFNL1-associated genes across cancer lineages are PKN3, SRR, and ELP5. Each is linked with SLFNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFNL1-to-partner and partner-to-SLFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by SLFNL1-low versus SLFNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFNL1→partner) and Y-score (partner→SLFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.615	+2.147	.001	.009	3	2
UCEC	SRR →	+0.654	+3.258	<.001	<.001	3	2
UCEC	ELP5 →	+0.370	+2.119	.004	.003	3	2
UCEC	MSANTD3 →	+0.458	+2.238	.005	.006	3	2
UCEC	RNU6-961P →	+0.072	+3.812	<.001	.008	3	2
UCEC	RNU6-1029P →	+0.237	+2.123	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

PKN3 by SLFNL1 expression — UCEC

Explore this box plot interactively →