SLFNL1

Across TCGA patient cohorts, SLFNL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFNL1-associated genes across cancer lineages are ERK2, PCNA, and Annexin-1. Each is linked with SLFNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFNL1-to-partner and partner-to-SLFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SLFNL1-low versus SLFNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFNL1→partner) and Y-score (partner→SLFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.194	+3.169	.017	.018	3	2
UCEC	PCNA →	+0.216	+2.321	.018	.034	3	1
UCEC	Annexin-1 →	+0.746	+3.459	<.001	.005	3	1
UCEC	STAT3_pY705 →	-0.338	-2.311	.002	.034	3	1
UCEC	ATM →	-0.435	-2.986	.023	.035	3	1
UCEC	c-Kit →	-0.211	-2.302	.033	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by SLFNL1 expression — UCEC

Explore this box plot interactively →