SLFNL1

Across TCGA cell cohorts, SLFNL1 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLFNL1-associated genes across cancer lineages are LYG1, FANCD2OS, and NLRC3. Each is linked with SLFNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFNL1-to-partner and partner-to-SLFNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by SLFNL1-low versus SLFNL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFNL1→partner) and Y-score (partner→SLFNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+1.191	+3.082	<.001	.007	3	1
LARGE_INTESTINE	FANCD2OS →	+0.108	+3.584	.002	.002	3	1
LARGE_INTESTINE	NLRC3 →	+0.132	+3.266	.001	.005	3	1
LARGE_INTESTINE	OR2AT4 →	+0.012	+2.518	.006	.006	3	1
LARGE_INTESTINE	DPY19L2 →	+0.399	+3.478	.009	.002	3	1
LARGE_INTESTINE	FOXE3 →	+0.115	+3.389	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

LYG1 by SLFNL1 expression — LARGE_INTESTINE

Explore this box plot interactively →