SLFN14

Across TCGA patient cohorts, SLFN14 mutation is significantly associated with the RNA expression of many other genes, with 3,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN14-associated genes across cancer lineages are LINC02559, PLA2G3, and SLC25A17. Each is linked with SLFN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN14-to-partner and partner-to-SLFN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by SLFN14-low versus SLFN14-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN14→partner) and Y-score (partner→SLFN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.780	+6.342	<.001	.001	3	2
UCEC	PLA2G3 →	+0.772	+2.000	<.001	.001	3	2
UCEC	SLC25A17 →	+0.315	+2.446	.003	.001	3	2
UCEC	IL2RB →	+0.735	+1.726	.001	.002	3	2
COAD	GZMH →	+1.011	+3.321	.001	.009	3	2
UCEC	RBFA →	+0.371	+2.732	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,575 associations by consensus.

LINC02559 by SLFN14 expression — CESC

Explore this box plot interactively →