SLFN14

Across TCGA patient cohorts, SLFN14 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN14-associated genes across cancer lineages are 14-3-3_beta, FASN, and Shc_pY317. Each is linked with SLFN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN14-to-partner and partner-to-SLFN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SLFN14-low versus SLFN14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN14→partner) and Y-score (partner→SLFN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.206	-3.144	.041	.019	3	2
UCEC	FASN →	+0.307	+1.700	.030	.042	3	2
UCEC	Shc_pY317 →	-0.167	-1.925	.002	.005	3	2
UCEC	ASNS →	+0.581	+2.999	<.001	<.001	3	2
UCEC	ATM →	-0.481	-2.687	.003	.005	3	2
UCEC	4E-BP1 →	+0.469	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

14-3-3_beta by SLFN14 expression — COAD

Explore this box plot interactively →