SLFN14

Across TCGA cell cohorts, SLFN14 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,218 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLFN14-associated GO terms across cancer lineages are Viral process, Regulation of extrinsic apoptotic signaling pathway via death domain receptors, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with SLFN14 in more than 8 cancer types. Because this analysis shows association rather than direction, both SLFN14-to-partner and partner-to-SLFN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral process grouped by SLFN14-low versus SLFN14-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN14→partner) and Y-score (partner→SLFN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Viral process →	+0.054	+1.227	<.001	<.001	3	9
LARGE_INTESTINE	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.121	+0.011	<.001	.009	2	9
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.103	+0.023	<.001	<.001	3	8
OVARY	Negative regulation of myoblast fusion →	+0.111	+0.022	<.001	<.001	3	8
OVARY	Regulation of proteasomal protein catabolic process →	+0.049	+0.020	.001	<.001	3	8
CNS	Regulation of response to cytokine stimulus →	+0.049	+0.032	<.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,218 associations by consensus.

Viral process by SLFN14 expression — BLOOD_Leukemia

Explore this box plot interactively →