SLFN14

Across TCGA cell cohorts, SLFN14 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLFN14-associated genes across cancer lineages are KRTAP10-4 and GPR142. Each is linked with SLFN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN14-to-partner and partner-to-SLFN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-4 grouped by SLFN14-low versus SLFN14-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN14→partner) and Y-score (partner→SLFN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP10-4 →	+0.015	+5.022	<.001	.002	3	1
SKIN	GPR142 →	+0.019	+4.930	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

KRTAP10-4 by SLFN14 expression — SKIN

Explore this box plot interactively →