SLFN13

Across TCGA pan-cancer cohorts, SLFN13 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLFN13 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLFN13 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLFN13 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where SLFN13 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.142	0.673	.001	39	view →
UCEC	DFS	Median	All	1.000	0.826	.004	36	view →
SKCM	DFS	Median	II,III,IV	0.313	0.606	.007	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLFN13–HNSC (OS)

Open the HNSC breakdown →