SLFN13

Across TCGA patient cohorts, SLFN13 mutation is significantly associated with the RNA expression of many other genes, with 3,319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN13-associated genes across cancer lineages are SKA1, RNASEH1, and PPP2R2D. Each is linked with SLFN13 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLFN13-to-partner and partner-to-SLFN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by SLFN13-low versus SLFN13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN13→partner) and Y-score (partner→SLFN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.729	+2.010	<.001	<.001	3	3
SKCM	RNASEH1 →	+0.450	+2.820	<.001	.001	3	3
UCEC	PPP2R2D →	+0.351	+3.191	<.001	<.001	3	3
UCEC	RAD51 →	+0.769	+3.180	<.001	<.001	3	3
SKCM	PKM →	+0.444	+2.143	.003	<.001	3	3
UCEC	BIRC5 →	+0.632	+4.119	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,319 associations by consensus.

SKA1 by SLFN13 expression — UCEC

Explore this box plot interactively →