SLFN13

Across TCGA cell cohorts, SLFN13 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,648 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SLFN13-associated GO terms across cancer lineages are Xenophagy, Cytoplasmic pattern recognition receptor signaling pathway, and Cellular response to abiotic stimulus. Each is linked with SLFN13 in more than 11 cancer types. Because this analysis shows association rather than direction, both SLFN13-to-partner and partner-to-SLFN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Xenophagy grouped by SLFN13-low versus SLFN13-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN13→partner) and Y-score (partner→SLFN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Xenophagy →	+0.200	+1.693	<.001	<.001	3	12
SOFT_TISSUE	Cytoplasmic pattern recognition receptor signaling pathway →	+0.069	+1.318	<.001	.001	3	11
LUNG_NSCLC_LUSC	Cellular response to abiotic stimulus →	+0.043	+2.324	.006	.002	2	11
OVARY	Regulation of myoblast fusion →	+0.073	+1.629	<.001	<.001	3	10
BLOOD_Lymphoma	CD8-positive, alpha-beta T cell activation →	+0.106	+1.713	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Cellular response to radiation →	+0.039	+1.528	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,648 associations by consensus.

Xenophagy by SLFN13 expression — BLOOD_Lymphoma

Explore this box plot interactively →