SLFN13

Across TCGA cell cohorts, SLFN13 mutation is significantly associated with the RNA expression of many other genes, with 619 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLFN13-associated genes across cancer lineages are TMEM135, FAM229B, and GCLM. Each is linked with SLFN13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN13-to-partner and partner-to-SLFN13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM135 grouped by SLFN13-low versus SLFN13-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN13→partner) and Y-score (partner→SLFN13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM135 →	+0.618	+3.489	.007	.001	3	2
BLOOD_Leukemia	FAM229B →	+0.955	+3.260	.001	.005	3	2
LARGE_INTESTINE	GCLM →	+0.798	+3.502	.002	.001	3	2
BLOOD_Leukemia	PDXP →	+0.583	+3.489	.003	.001	3	2
LARGE_INTESTINE	SNW1 →	+0.574	+3.588	<.001	<.001	3	2
LARGE_INTESTINE	UBE3A →	+0.729	+3.082	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 619 associations by consensus.

TMEM135 by SLFN13 expression — BLOOD_Leukemia

Explore this box plot interactively →