SLFN12L

Across TCGA cell cohorts, SLFN12L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,690 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLFN12L-associated GO terms across cancer lineages are Cellular response to environmental stimulus, Cellular response to abiotic stimulus, and Nucleoside diphosphate metabolic process. Each is linked with SLFN12L in more than 12 cancer types. Because this analysis shows association rather than direction, both SLFN12L-to-partner and partner-to-SLFN12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to environmental stimulus grouped by SLFN12L-low versus SLFN12L-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12L→partner) and Y-score (partner→SLFN12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to environmental stimulus →	+0.035	+0.155	.002	.003	2	13
UPPER_AERODIGESTIVE_TRACT	Cellular response to abiotic stimulus →	+0.035	+0.155	.002	.003	2	13
LUNG_NSCLC_LUSC	Nucleoside diphosphate metabolic process →	+0.084	+0.542	<.001	.003	3	9
BREAST	Negative regulation of post-translational protein modification →	+0.094	+0.218	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of protein modification by small protein conjugation or removal →	+0.109	+0.402	<.001	.002	3	9
BREAST	Negative regulation of protein modification process →	+0.045	+0.218	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,690 associations by consensus.

Cellular response to environmental stimulus by SLFN12L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →