SLFN12L

Across TCGA cell cohorts, SLFN12L mutation is significantly associated with the mutation status of many other genes, with 2,247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLFN12L-associated genes across cancer lineages are DAAM2, DDX60L, and FLNB. Each is linked with SLFN12L in more than 4 cancer types. Because this analysis shows association rather than direction, both SLFN12L-to-partner and partner-to-SLFN12L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAAM2 grouped by SLFN12L-low versus SLFN12L-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12L→partner) and Y-score (partner→SLFN12L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DAAM2 →	+5.772	+5.772	.002	.002	1	5
LUNG_NSCLC_LUSC	DDX60L →	+4.228	+4.228	.004	.004	1	4
BLOOD_Leukemia	FLNB →	+2.285	+3.364	.006	.006	1	4
BLOOD_Leukemia	AMOTL1 →	+3.285	+3.662	.004	.004	1	4
BLOOD_Leukemia	DCDC1 →	+2.700	+3.741	.002	.002	1	4
BLOOD_Leukemia	NEXMIF →	+2.870	+3.347	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,247 associations by consensus.

DAAM2 by SLFN12L expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →