SLFN12

Across TCGA patient cohorts, SLFN12 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,065 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SLFN12-associated proteins across cancer lineages are PPP1R12A, PML, and UBA7. Each is linked with SLFN12 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLFN12-to-partner and partner-to-SLFN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLFN12 versus PPP1R12A in LUAD, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12→partner) and Y-score (partner→SLFN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP1R12A →	+0.190	+0.553	<.001	.001	3	6
GBM	PML →	+0.410	+0.565	<.001	<.001	3	6
BRCA	UBA7 →	+0.506	+1.123	<.001	<.001	3	5
OV	VIM_S22 →	+1.262	+0.625	<.001	<.001	3	5
PDAC	COQ3 →	-0.289	-0.409	.001	<.001	3	5
BRCA	ILK →	+0.446	+0.997	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,065 associations by consensus.

SLFN12 vs PPP1R12A — LUAD

Explore this scatter interactively →