SLFN12

Across TCGA patient cohorts, SLFN12 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN12-associated genes across cancer lineages are Stathmin, Chk2, and beta-Catenin. Each is linked with SLFN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN12-to-partner and partner-to-SLFN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by SLFN12-low versus SLFN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12→partner) and Y-score (partner→SLFN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.150	+2.115	.012	.019	3	2
UCEC	Chk2 →	-0.252	-2.807	.013	.003	3	2
SKCM	beta-Catenin →	-0.701	-3.459	.002	.005	3	2
SKCM	E-Cadherin →	-0.932	-2.000	.017	.031	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.807	.013	.003	3	1
UCEC	MEK1 →	+0.405	+2.459	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Stathmin by SLFN12 expression — UCEC

Explore this box plot interactively →