SLFN12

Across TCGA cell cohorts, SLFN12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,774 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLFN12-associated GO terms across cancer lineages are Regulation of intracellular protein transport, Membrane assembly, and Regulation of protein K48-linked ubiquitination. Each is linked with SLFN12 in more than 12 cancer types. Because this analysis shows association rather than direction, both SLFN12-to-partner and partner-to-SLFN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular protein transport grouped by SLFN12-low versus SLFN12-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12→partner) and Y-score (partner→SLFN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of intracellular protein transport →	+0.073	+1.565	<.001	<.001	3	13
OESOPHAGUS	Membrane assembly →	+0.104	+2.221	<.001	<.001	3	12
BREAST	Regulation of protein K48-linked ubiquitination →	+0.158	+1.760	<.001	<.001	3	12
BREAST	Negative regulation of post-translational protein modification →	+0.064	+1.263	<.001	.002	3	12
BONE	Vesicle-mediated transport to the plasma membrane →	+0.078	+2.728	.002	<.001	3	12
BREAST	Pyrimidine-containing compound transmembrane transport →	-0.176	-1.495	<.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,774 associations by consensus.

Regulation of intracellular protein transport by SLFN12 expression — BREAST

Explore this box plot interactively →