SLFN12

Across TCGA cell cohorts, SLFN12 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLFN12-associated genes across cancer lineages are LECT2, C3orf85, and KCNK17. Each is linked with SLFN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN12-to-partner and partner-to-SLFN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LECT2 grouped by SLFN12-low versus SLFN12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN12→partner) and Y-score (partner→SLFN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LECT2 →	+0.186	+4.922	<.001	.009	3	1
BLOOD_Leukemia	C3orf85 →	+0.059	+5.539	<.001	.003	3	1
LARGE_INTESTINE	KCNK17 →	+0.051	+2.906	.003	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	EFHC2 →	+0.497	+3.555	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LECT2 by SLFN12 expression — BLOOD_Leukemia

Explore this box plot interactively →