SLFN11

Across TCGA pan-cancer cohorts, SLFN11 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SLFN11 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLFN11 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SLFN11 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, LUAD, and CESC are the cancer types where SLFN11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.951	0.609	.002	32	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	24	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
LIHC	OS	Median	II,III,IV	0.439	0.718	.006	11	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
SKCM	OS	Median	III,IV	0.302	0.744	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.170	0.562	.024	5	view →
BLCA	OS	Median	II,III,IV	1.000	0.708	.032	4	view →
STAD	OS	Median	IV	0.111	0.433	.002	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SLFN11–UCEC (DFS)

Open the UCEC breakdown →