SLFN11

Across TCGA pan-cancer cohorts, SLFN11 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLFN11 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SLFN11 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLFN11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where SLFN11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.530	0.882	.011	27	view →
CCRCC	OS	Median	All	0.826	0.953	.019	26	view →
HNSC	DFS	Tertile	III,IV	0.810	0.185	.008	20	view →
OV	DFS	Quartile	All	0.377	0.896	.006	8	view →
PDAC	DFS	Median	II,III,IV	0.290	0.481	.002	8	view →
UCEC	DFS	Tertile	III,IV	1.000	0.328	.022	4	view →
GBM	DFS	Median	All	0.297	0.451	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLFN11–LSCC (DFS)

Open the LSCC breakdown →