SLFN11

Across TCGA patient cohorts, SLFN11 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,116 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SLFN11-associated proteins across cancer lineages are TBC1D2B, CTHRC1, and DOCK11. Each is linked with SLFN11 in more than 7 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLFN11 versus TBC1D2B in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBC1D2B →	+0.283	+0.693	<.001	.001	3	8
OV	CTHRC1 →	+0.987	+0.765	<.001	<.001	3	7
OV	DOCK11 →	+0.473	+0.537	<.001	.002	3	7
COAD	DPYD →	+0.442	+0.641	<.001	<.001	3	7
LUAD	P4HA2 →	+0.603	+0.703	<.001	<.001	3	7
BRCA	ACTB →	+0.572	+0.846	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,116 associations by consensus.

SLFN11 vs TBC1D2B — GBM

Explore this scatter interactively →