SLFN11

Across TCGA patient cohorts, SLFN11 protein abundance is significantly associated with the RNA expression of many other genes, with 12,322 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SLFN11-associated genes across cancer lineages are CD180, ADPRH, and LILRB1. Each is linked with SLFN11 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SLFN11 versus CD180 in HNSC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD180 →	+0.798	+0.358	<.001	<.001	3	6
LSCC	ADPRH →	+0.592	+0.428	<.001	<.001	3	6
HNSC	LILRB1 →	+0.932	+0.307	<.001	<.001	3	5
HNSC	ST8SIA4 →	+0.741	+0.318	<.001	<.001	3	5
BRCA	CD86 →	+0.796	+0.411	<.001	<.001	3	5
HNSC	HAVCR2 →	+0.803	+0.242	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,322 associations by consensus.

SLFN11 vs CD180 — HNSC

Explore this scatter interactively →