SLFN11

Across TCGA patient cohorts, SLFN11 mutation is significantly associated with the RNA expression of many other genes, with 2,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN11-associated genes across cancer lineages are SNRPGP7, MRPL44, and GRHPR. Each is linked with SLFN11 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by SLFN11-low versus SLFN11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPGP7 →	+0.475	+4.602	<.001	<.001	3	5
UCEC	MRPL44 →	+0.370	+1.446	.002	.005	3	4
UCEC	GRHPR →	+0.289	+1.606	.005	<.001	3	4
UCEC	H2AZ1 →	+0.485	+1.617	<.001	<.001	3	4
SKCM	IDI2 →	+0.180	+1.477	<.001	.003	3	3
SKCM	MCRIP2 →	+0.397	+2.260	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,788 associations by consensus.

SNRPGP7 by SLFN11 expression — COAD

Explore this box plot interactively →