SLFN11

Across TCGA patient cohorts, SLFN11 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLFN11-associated genes across cancer lineages are p21, PREX1, and SF2. Each is linked with SLFN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by SLFN11-low versus SLFN11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p21 →	-0.492	-2.584	<.001	.009	3	2
SKCM	PREX1 →	-0.250	-1.857	.022	.002	3	2
SKCM	SF2 →	-0.102	-1.321	.027	.028	3	2
UCEC	eEF2 →	+0.298	+2.321	.006	.005	3	2
UCEC	eIF4E →	+0.137	+2.321	.033	<.001	3	2
UCEC	MEK1 →	+0.298	+2.137	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

p21 by SLFN11 expression — SKCM

Explore this box plot interactively →