SLFN11

Across TCGA cell cohorts, SLFN11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,673 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SLFN11-associated GO terms across cancer lineages are Cellular response to environmental stimulus, Negative regulation of protein modification process, and Cellular response to abiotic stimulus. Each is linked with SLFN11 in more than 10 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to environmental stimulus grouped by SLFN11-low versus SLFN11-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.041	+2.037	<.001	.002	3	10
LUNG_SCLC	Negative regulation of protein modification process →	+0.043	+2.628	.002	.001	3	10
SOFT_TISSUE	Cellular response to abiotic stimulus →	+0.041	+2.037	<.001	.002	3	10
SOFT_TISSUE	Regulation of post-translational protein modification →	+0.052	+2.985	<.001	<.001	3	9
BLOOD_Leukemia	Negative regulation of post-translational protein modification →	+0.059	+1.661	<.001	.002	2	10
SOFT_TISSUE	Regulation of protein modification by small protein conjugation or removal →	+0.057	+2.507	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,673 associations by consensus.

Cellular response to environmental stimulus by SLFN11 expression — SOFT_TISSUE

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