SLFN11

Across TCGA cell cohorts, SLFN11 mutation is significantly associated with the mutation status of many other genes, with 5,020 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLFN11-associated genes across cancer lineages are UPF2, TENM1, and FARP1. Each is linked with SLFN11 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLFN11-to-partner and partner-to-SLFN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UPF2 grouped by SLFN11-low versus SLFN11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLFN11→partner) and Y-score (partner→SLFN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UPF2 →	+2.962	+2.399	.002	.002	1	5
BLOOD_Leukemia	TENM1 →	+3.488	+3.130	<.001	<.001	1	5
BREAST	FARP1 →	+5.297	+5.297	.004	.004	1	4
LARGE_INTESTINE	CPS1 →	+1.951	+3.015	.006	.006	1	4
LUNG_NSCLC_LUAD	HECW2 →	+5.303	+4.339	<.001	<.001	1	4
LUNG_NSCLC_LUAD	NLRP2 →	+3.455	+5.071	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,020 associations by consensus.

UPF2 by SLFN11 expression — BLOOD_Leukemia

Explore this box plot interactively →