SLF1

Across TCGA pan-cancer cohorts, SLF1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated SLF1 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLF1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLF1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

ACC, THYM, and HNSC are the cancer types where SLF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	III,IV	0.079	0.746	<.001	24	view →
OV	OS	Median	II,III,IV	0.261	0.843	.010	18	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
CESC	OS	Median	II,III,IV	0.227	0.759	.029	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
SCLC	OS	Median	All	0.082	0.653	.002	6	view →
LIHC	OS	Median	All	0.255	0.773	.012	6	view →
SKCM	DFS	Median	II,III,IV	0.216	0.685	.003	3	view →
LUSC	DFS	Median	All	0.782	0.382	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SLF1–ACC (DFS)

Open the ACC breakdown →