Across TCGA patient cohorts, SLCO6A1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO6A1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and Chk2_pT68. Each is linked with SLCO6A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO6A1-to-partner and partner-to-SLCO6A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO6A1→partner) and Y-score (partner→SLCO6A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.222	+3.342	.003	.004	3	3
STAD	Caspase-7-cleavedD198 →	+0.711	+3.000	.022	.034	3	3
LUSC	Chk2_pT68 →	+0.127	+3.183	.012	.009	3	3
COAD	ASNS →	+0.855	+3.178	<.001	.010	3	3
LUAD	4E-BP1 →	+0.503	+2.820	.002	.035	3	3
UCEC	Cyclin-B1 →	+0.684	+2.999	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

SLCO6A1 survival (RNA) · tumor vs normal (RNA) · all SLCO6A1 data types