SLCO4C1

Across TCGA patient cohorts, SLCO4C1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO4C1-associated genes across cancer lineages are eIF4E, TAZ, and Cyclin-B1. Each is linked with SLCO4C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO4C1-to-partner and partner-to-SLCO4C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLCO4C1-low versus SLCO4C1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO4C1→partner) and Y-score (partner→SLCO4C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.148	+3.169	.019	.017	3	3
SKCM	TAZ →	+0.147	+1.887	.009	.029	3	2
UCEC	Cyclin-B1 →	+0.625	+2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.076	-2.673	.023	.005	3	2
COAD	eEF2 →	+0.339	+3.178	.020	.010	3	2
UCEC	GAPDH →	+0.452	+2.222	.011	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by SLCO4C1 expression — SKCM

Explore this box plot interactively →