SLCO4C1

Across TCGA cell cohorts, SLCO4C1 mutation is significantly associated with the RNA expression of many other genes, with 391 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO4C1-associated genes across cancer lineages are TEX101, OR51I2, and CYP26C1. Each is linked with SLCO4C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO4C1-to-partner and partner-to-SLCO4C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX101 grouped by SLCO4C1-low versus SLCO4C1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO4C1→partner) and Y-score (partner→SLCO4C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX101 →	+0.179	+2.971	<.001	.003	3	2
BLOOD_Lymphoma	OR51I2 →	+0.095	+4.523	<.001	.004	3	2
SKIN	CYP26C1 →	+0.243	+3.906	<.001	.005	3	1
SKIN	PSMB11 →	+0.018	+4.392	<.001	.004	3	1
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.822	+3.459	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 391 associations by consensus.

TEX101 by SLCO4C1 expression — LARGE_INTESTINE

Explore this box plot interactively →